Feasibility
Structural druggability and target accessibility assessment.
Leading Computational Design
Engineering Proteins.
AffiniBind™ designs candidate binders with three complementary engines, and twelve quality checks, so only the most promising candidates reach the lab.
The Platform
The AffiniBind Workflow
Cutting-edge pipeline from target preparation through results export, engineered for process transparency at every gate.
- 1
Target Preparation
Structure cleaning, residue table construction, and surface characterization.
- 2
Surface Fingerprinting
Four complementary models score every surface residue for binding potential.
- 3
Patch Identification
High-scoring residues clustered into ranked binding patches with 3D visualization.
- 4
Binder Generation
Three generative engines produce diverse candidates on cloud GPU infrastructure.
Interface Precision
Interactive Hotspot Mapping
The AffiniBind surface fingerprinting pipeline combines ScanNet, MaSIF, MPBind, and APBS electrostatics to identify critical interface residues, validated on 223 complexes from the gold-standard DB5.5 docking benchmark with a 96.4% Top-3 patch hit rate. Read the benchmark analysis →
- pLDDT confidence scoringPer-residue structural confidence resolves which contacts can be trusted.
The Development Pathway
A rigorous six-stage progression with explicit advancement criteria at every gate, from feasibility through validated assay.
Step 01 Step 02 Discovery
Generative design and sequence-to-library generation.
Step 03 Screening
IVTT expression and proximity assay screening.
Step 04 Validation
Functional assays and off-target cross-reactivity profiling.
Step 05 Assay
Validated binder delivered assay-ready with a characterized performance package.
Open Design Campaigns
View All TargetsActive community-driven design challenges
Participate in community-driven protein design challenges and follow live candidate progress.
Start Your Project
Submit your target requirements to initiate a feasibility review. Our engineering team will respond within two business days.
- 1Your Details
- 2Project Scope
- 3Target Info
- 4Submit & Review
Engineering-Led Development
Engineer your binder with AffiniBind.
Bring us a target. We will return high-confidence, assay-aware candidates built to survive experimental validation.
