Diagnostics & Biosensing
Binders engineered for ELISA, lateral flow, and biosensor formats, selected for the surface chemistry, signal kinetics, and matrix conditions of the final assay.
Mission Statement
Bridging the gap between computational sequence design and clinical assay performance.
Assay-aware protein engineering: WeaveSeq focuses on the design, optimization, and translation of custom protein binders. Our mission is to accelerate the development of custom binding proteins through sequence-driven engineering and practical design that accounts for real-world assay conditions.
What We Do
Biodefense & Environmental
Affinity reagents for biodefense and environmental monitoring, where ruggedness, specificity, and field-ready stability govern candidate selection.
Research Reagents & Recognition
Custom binders, affinity reagents, and engineered proteins for research and broader molecular-recognition applications across multiple domains.
Our Philosophy
Assay-Aware Protein Design
Most computational protein design workflows optimize primarily for predicted binding affinity. AffiniBind™ is designed to prioritize candidates more likely to survive downstream experimental development and assay translation, what we think of as contextual biologics.
- Developability & ManufacturabilityCandidates are screened for expression, stability, and manufacturability, prioritizing binders likely to survive recombinant production and scale-up.
- Assay Compatibility & SpecificityStructural confidence, interface quality, and predicted specificity are weighed against the downstream assay format from the first design steps.
Scientific Credibility
Rooted in diagnostic assay development.
WeaveSeq™ focuses on the complete path from sequence to experimentally evaluated binding proteins. The team draws on practical experience in assay development, diagnostic reagent optimization, and manufacturing transfer, so computational candidates are judged against the realities of the wet lab.
- ELISA & Lateral Flow
Practical experience developing ELISA and lateral-flow assays, transitioning binding-protein leads into validated diagnostic reagent formats.
- QC & Manufacturing Transfer
Candidates evaluated for high-yield expression and quality control, with manufacturing-transfer considerations built into selection.
- Signal Kinetics
Association and dissociation behavior modeled so candidates are matched to the diagnostic window of the intended assay.
- Data Transparency
Every stage delivers objective metrics: pLDDT, interface PAE, contacts, clash, specificity; with documented decision points rather than a black box.
- Benchmark-Validated Predictions
The surface fingerprinting pipeline has been validated against the DB5.5 docking benchmark: 96.4% Top-3 patch hit rate across 223 protein-protein complexes. Read the analysis →
Workflow Transparency
From sequence to validated solution
Every stage carries predefined deliverables, advancement criteria, and objective evaluation metrics, a transparent, repeatable engineering process rather than a black-box discovery workflow.
- 1
Computational In-Silico
Target analysis, binder generation, and structural validation with confidence scoring before any experimental resources are committed.
- 2
Rapid Prototyping
Expression and binding evaluation of prioritized candidates against predefined advancement criteria.
- 3
Deployment QC
Functional testing, kinetic profiling, and assay development to deliver a characterized, assay-ready reagent.
6
Development StagesGo / No-Go
Decision Per StageSeq → Assay
End-to-End Pathway10-12M
Affinity ResolutionLong-Term Vision
Build a scalable platform for molecular recognition across applications.
From binders and affinity reagents to engineered proteins and future recognition systems. WeaveSeq is building a sequence-driven engineering platform for the long run. Bring us your target.