WeaveSeq provides a staged pathway from computational binder generation to experimentally validated, assay-ready binding proteins. Each stage carries defined deliverables and advancement criteria before resources are committed to the next phase, reducing risk while concentrating effort on the most promising candidates.
Six technical gates take a target from feasibility review to a validated, assay-ready reagent.
At the center of the workflow is AffiniBind™, WeaveSeq's computational binder engineering platform. Every stage generates objective data used to decide whether candidates continue, are modified, or are eliminated.
Determine whether a target is suitable for computational binder engineering and downstream assay development.
AdvancementTarget is determined to be suitable for AffiniBind™ discovery.
Generate and prioritize candidate binding proteins.
AdvancementOne or more candidates satisfy predefined computational quality thresholds.
Rapidly evaluate candidate binders via cell-free expression before committing to recombinant production.
AdvancementOne or more candidates demonstrate measurable target engagement and acceptable screening performance.
Determine whether candidate binders satisfy application-specific performance requirements.
AdvancementOne or more candidates satisfy predefined functional requirements.
Produce prioritized binders using scalable recombinant expression methods.
AdvancementOne or more candidates can be successfully expressed and purified while maintaining acceptable performance.
Translate validated binders into practical assay formats.
AdvancementA validated binder is delivered in an assay-ready format with a characterized performance package.
Projects advance through clearly defined technical gates. Advancement between stages is based on predefined criteria, so resources are concentrated on the most promising candidates while transparency is maintained from sequence to validated binding protein.
Engagements range from a focused feasibility review to a dedicated end-to-end program. You receive a data package and recommendation at each stage and decide whether to continue, pause, or redirect development.
Ideal for customers evaluating a new target. Determine whether a target is suitable for computational binder engineering: structural review, surface accessibility analysis, epitope assessment, and assay-geometry evaluation. Delivers a target feasibility report and Go / No-Go recommendation.
Target review through computational binder generation. Includes AffiniBind discovery: candidate binder generation, structural validation, developability screening, and specificity evaluation. Delivers a ranked candidate set with full metrics and development recommendations.
Includes AffiniBind discovery and IVTT evaluation. After computational generation, candidates are rapidly screened via cell-free expression to identify those with measurable target engagement before committing to recombinant production. Accelerates design-test cycles and eliminates poor performers early.
Includes AffiniBind discovery, IVTT screening, and recombinant production. After computational generation and cell-free screening, prioritized binders are produced at scale in E. coli, delivering purified, characterized candidates ready for functional testing.
Includes recombinant production and functional testing. Prioritized binders are produced at scale in E. coli, purified, and evaluated in application-relevant functional formats: proximity assays, competitive binding, target capture studies. Delivers functional performance data and comparative ranking.
An end-to-end engagement spanning the complete pathway: target assessment through recombinant production, functional validation, and assay development for a deployable reagent. Delivers an assay-ready binder with full documentation, optimization report, and initial performance package.
Start with a feasibility review or commit to the full pathway. Either way, you work directly with our engineering team and decide at every gate.