Geometric Complementarity in Interface Engineering
Designing steric fit and electrostatic patterns to maximize specificity in therapeutic protein–protein interactions.
Designing steric fit and electrostatic patterns to maximize specificity in therapeutic protein–protein interactions.
Explore more from this discipline or browse the full archive.
A surface-fingerprinting and parallel binder generation campaign against staphylococcal enterotoxin B2 produced 28 developability-scored candidates, with bindcraft designs dominating the top ranks by generator confidence.

Send us a target surface and we will scope a feasibility review, design binders, and report the same objective metrics our research is built on.
Methods for introducing multiple paratopes onto a single rigid framework without compromising core stability.

Navigating the challenges of off-target interactions and non-specific binding in physiological environments.