Assay Development
2 min
High-Throughput Validation of Synthetic Binders
High-throughput validation of synthetic binders: a three-tier SPR and BLI screen that clears 80–90% of candidates before kinetics on the top 10–20%.
Knowledge Center
Knowledge Center
WeaveSeq Engineering Division: protein binders, hotspot selection, interface design, assay development, and diagnostic translation, built on AffiniBind™.
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FeaturedPipeline Validation
12 min read
WeaveRank Enriches Binder Hits 1.6-Fold: Validation on 1,880 Literature Designs
Built on 3,414 literature designs and tested on 1,880 it had never seen: sorting by WeaveRank puts a median four binders in the top 10, 1.6× the target's own base rate.
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Assay Development3 minQuantifying Binding Kinetics in Complex Serum
How non-specific binding and viscosity shift measured kinetics: an EGFR binder drops from 1.3 nM to 4.4 nM K_D in 50% serum, recovering to 1.8 nM on a PEG surface.
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WeaveRank Validation Across 1,880 Literature Designs