Protein Binders
3 min
The Architecture of De Novo Protein Binders
How synthetic protein design sets its structural requirements, from thermodynamic stability to the binding-affinity benchmarks that matter in therapeutic development.
Knowledge Center
Knowledge Center
WeaveSeq Engineering Division: protein binders, hotspot selection, interface design, assay development, and diagnostic translation, built on AffiniBind™.
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FeaturedPipeline Validation
12 min read
WeaveRank Enriches Binder Hits 1.6-Fold: Validation on 1,880 Literature Designs
Built on 3,414 literature designs and tested on 1,880 it had never seen: sorting by WeaveRank puts a median four binders in the top 10, 1.6× the target's own base rate.
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Protein Binders3 minScaffold Engineering for Multispecific Binding
Scaffold engineering for multispecific binding: paratope placement rules that hold ≥ 25 Å separation, ΔG_folding ≤ −8 kcal/mol, and 4–6 paratopes per scaffold.
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Every article documents a method, a dataset, or a result from the AffiniBind pipeline. Start with the benchmark that anchors the rest.
WeaveRank Validation Across 1,880 Literature Designs