Candidate ranking · Binding & developability assessment

STAPHYLOCOCCAL ENTEROTOXIN B

SEB_02_bindcraft_binder_001

PromisingRanked by WeaveRankPatch P01bindcraft60 aa

Loading structure…

Representation

ENIYKWMTDEKWEEYMEILKEAHEQIENGGLVETEKGIEKKKPEEIIKEAEEKFEELMKK

60 residues

PRODIGY Kd99th

6.70e-63.40e-10

BindPred log₁₀Kd96th

-4.6-8.2

PRODIGY ΔG99th

-7-12.9

3D-SAP51th

0.1-3.7

Solubility42th

0.40.8

pI72th

10.14.2

WeaveRank78th

-1.52.1

RMSD23th

12.30.2

EpitopeE01

Interface SASA53.2%

Interface Hydrophob.58.3%

Surface Hydrophob.0.24

dSASA2220

Shape Complementarity0.62

Interface Residues24

Binder RMSD2.1Å

Hotspot RMSD3Å

Unrelaxed Clashes1

Binder

Binder Helix60.0%

Binder Loop26.7%

Interface

Interface Helix77.8%

Interface Loop22.2%

MPNN Score0.83

Seq Recovery0.51

AF2 pLDDT0.89

iPTM0.85

pTM0.91

iPAE0.21

Binder pLDDT0.86

Binder pTM0.62

Binder PAE0.19

WeaveRank

Generator filter: passed

+1.43ensemble rank z · IVTT construct A9

Mean of the member z-scores: structural interface-confidence ensemble (ESMFold2 co-fold), not a lab measurement.

Ensemble members

ESMFold LIS+1.65

ESMFold iPTM+1.51

ESMFold ipSAE (min)+1.89

ESMFold pLDDT (avg)+0.92

ESMFold interface PAE+1.17

Ensemble inputs

cofold ipSAE min0.62

cofold iPTM0.81

cofold pLDDT avg87.52

cofold LIS0.48

cofold iface PAE6.46

Display metrics

ESMFold pLDDT avg69.77

STAPHYLOCOCCAL ENTEROTOXIN B

STAPHYLOCOCCAL ENTEROTOXIN B

Binder Sequence

vs. Siblings (108 in target)

Epitope Context

Interface Quality

Structural Fit

Secondary Structure

MPNN Quality

AF2 Confidence

Risk Flags

Interface AA Composition

WeaveRank

Binder Sequence

vs. Siblings (108 in target)

Epitope Context

Interface Quality

Structural Fit

Secondary Structure

MPNN Quality

AF2 Confidence

Risk Flags

Interface AA Composition

WeaveRank