Hotspot Selection
08 min
Computational Strategies for Binding Hotspot Identification
Utilizing alanine scanning and molecular dynamics to pinpoint high-energy residues critical for intermolecular stabilization.
Knowledge Center
Knowledge Center
Method notes and reviews from the WeaveSeq Engineering Division: protein binders, hotspot selection, interface design, assay development, and diagnostic translation, built on AffiniBind™.
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FeaturedPipeline Validation
10 min read
Benchmarking Binding-Site Fingerprinting — DB5.5 Validation of the AffiniBind Pipeline
Evaluating the AffiniBind surface fingerprinting pipeline against 223 protein-protein complexes from the Docking Benchmark 5.5 — 87.9% patch hit rate, 96.4% Top-3, and 0.853 AUC on held-out test data.
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