Hotspot Selection
3 min
Computational Strategies for Binding Hotspot Identification
Computational hotspot identification: alanine scanning, FoldX and MD refine the 3–8 interface residues carrying ΔΔG ≥ 2 kcal/mol into hard design constraints.
Knowledge Center
Knowledge Center
WeaveSeq Engineering Division: protein binders, hotspot selection, interface design, assay development, and diagnostic translation, built on AffiniBind™.
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FeaturedPipeline Validation
12 min read
WeaveRank Enriches Binder Hits 1.6-Fold: Validation on 1,880 Literature Designs
Built on 3,414 literature designs and tested on 1,880 it had never seen: sorting by WeaveRank puts a median four binders in the top 10, 1.6× the target's own base rate.
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WeaveRank Validation Across 1,880 Literature Designs