Candidate SEB_01_A · STAPHYLOCOCCAL ENTEROTOXIN B2

SEB_01_All_Generators_bindcraft_binder_001

PromisingPatch P01bindcraft60 aa

Loading structure…

Representation

MLSPNEVKALELISKLSKEHQEGLKMIIDTHREYFKDTGEDEDAFFKQFVEDIEKKFGVK

60 residuesBinder chain BTarget chain A

Unified Score64th

0.70.8

Solubility82th

0.60.8

3D-SAP27th

-3.5-1.5

pI45th

4.49.8

Interface Core45th

2747

Interface Rim27th

1524

Scaffold Exposed9th

Scaffold Buried45th

024

Low-Conf. Interface60th

00.7

Interface pLDDT55th

65.492

Scaffold pLDDT45th

5895.3

Lys+Arg Exposed36th

0.61

Mean Exposure73th

0.30.4

Protease Motifs9th

Hydrophobic Patch0th

087

Hydrophobic Interface Patch36th

1529

Pos. Charge Cluster45th

718

Neg. Charge Cluster27th

1015

Max Loop Length55th

Loop Flexibility27th

0.10.2

Buried Unsatisfied36th

Packing Density27th

12.314.5

Min Packing Density64th

Hydrophobic Fraction55th

0.30.5

Charge Asymmetry45th

0.20.5

Exposed Hydrophobic0th

00.1

PRODIGY ΔG0th

-13.6-8.7

PRODIGY Kd0th

iPTM93th

0.10.9

RMSD38th

0.212.2

pLDDT69th

0.60.9

EpitopeE01

Target Contacts (35)

A:ASP42A:GLN43A:PHE44A:LEU45A:TYR46A:PHE47A:ASP48A:ILE50A:ARG65A:GLU67A:PHE68A:LYS69A:ASN70A:LYS71A:TYR89A:TYR91A:GLN92A:CYS93A:TYR94A:PHE95+15 more

Interface SASA49%

Interface Hydrophob.47.4%

Surface Hydrophob.0.29

dSASA1846.9

Shape Complementarity0.6

Interface Residues19

Binder RMSD0.57Å

Hotspot RMSD0.99Å

Unrelaxed Clashes1.5

Binder

Binder Helix78.3%

Binder Loop21.7%

Interface

Interface Helix94.3%

Interface Loop5.8%

MPNN Score0.98

Seq Recovery0.45

AF2 pLDDT0.89

iPTM0.84

pTM0.9

iPAE0.21

Binder pLDDT0.92

Binder pTM0.72

Binder PAE0.1

SEB_01_All_Generators_bindcraft_binder_001

PromisingPatch P01bindcraft60 aa

Loading structure…

Representation

MLSPNEVKALELISKLSKEHQEGLKMIIDTHREYFKDTGEDEDAFFKQFVEDIEKKFGVK

60 residuesBinder chain BTarget chain A

Unified Score64th

0.70.8

Solubility82th

0.60.8

3D-SAP27th

-3.5-1.5

pI45th

4.49.8

Interface Core45th

2747

Interface Rim27th

1524

Scaffold Exposed9th

Scaffold Buried45th

024

Low-Conf. Interface60th

00.7

Interface pLDDT55th

65.492

Scaffold pLDDT45th

5895.3

Lys+Arg Exposed36th

0.61

Mean Exposure73th

0.30.4

Protease Motifs9th

Hydrophobic Patch0th

087

Hydrophobic Interface Patch36th

1529

Pos. Charge Cluster45th

718

Neg. Charge Cluster27th

1015

Max Loop Length55th

Loop Flexibility27th

0.10.2

Buried Unsatisfied36th

Packing Density27th

12.314.5

Min Packing Density64th

Hydrophobic Fraction55th

0.30.5

Charge Asymmetry45th

0.20.5

Exposed Hydrophobic0th

00.1

PRODIGY ΔG0th

-13.6-8.7

PRODIGY Kd0th

iPTM93th

0.10.9

RMSD38th

0.212.2

pLDDT69th

0.60.9

EpitopeE01

Target Contacts (35)

A:ASP42A:GLN43A:PHE44A:LEU45A:TYR46A:PHE47A:ASP48A:ILE50A:ARG65A:GLU67A:PHE68A:LYS69A:ASN70A:LYS71A:TYR89A:TYR91A:GLN92A:CYS93A:TYR94A:PHE95+15 more

Interface SASA49%

Interface Hydrophob.47.4%

Surface Hydrophob.0.29

dSASA1846.9

Shape Complementarity0.6

Interface Residues19

Binder RMSD0.57Å

Hotspot RMSD0.99Å

Unrelaxed Clashes1.5

Binder

Binder Helix78.3%

Binder Loop21.7%

Interface

Interface Helix94.3%

Interface Loop5.8%

MPNN Score0.98

Seq Recovery0.45

AF2 pLDDT0.89

iPTM0.84

pTM0.9

iPAE0.21

Binder pLDDT0.92

Binder pTM0.72

Binder PAE0.1

Binder Sequence

vs. Siblings (29 in target)

Epitope Context

Interface Quality

Structural Fit

Secondary Structure

MPNN Quality

AF2 Confidence

Risk Flags

Interface AA Composition

STAPHYLOCOCCAL ENTEROTOXIN B2

Binder Sequence

vs. Siblings (29 in target)

Epitope Context

Interface Quality

Structural Fit

Secondary Structure

MPNN Quality

AF2 Confidence

Risk Flags

Interface AA Composition

STAPHYLOCOCCAL ENTEROTOXIN B2