Campaign Overview
- Campaigns
- 1
- Candidates
- 29
- Patches
- 10
- Top Unified Score
- 0.80
Target overview · Annotations & metadata
Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5 A resolution: implications for superantigen recognition by MHC class II molecules and T-cell receptors.
Enterotoxin type B
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of pro-inflammatory cytokines (PubMed:2303780, PubMed:25015819). Also causes the intoxication staphylococcal food poisoning syndrome (By similarity)