Candidate SEB_01_A · STAPHYLOCOCCAL ENTEROTOXIN B2

SEB_01_All_Generators_bindcraft_binder_004

PromisingPatch P01bindcraft60 aa

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Representation

MTDEEFVMGHVKAAKEMLEETKKNDPENYEKDRKVYIEYVQFLIDHYAPDLPRTAEELLS

60 residuesBinder chain BTarget chain A

Unified Score55th

0.70.8

Solubility64th

0.60.8

3D-SAP36th

-3.5-1.5

pI82th

4.49.8

Interface Core36th

2747

Interface Rim64th

1524

Scaffold Exposed9th

Scaffold Buried64th

024

Low-Conf. Interface60th

00.7

Interface pLDDT91th

65.492

Scaffold pLDDT55th

5895.3

Lys+Arg Exposed64th

0.61

Mean Exposure64th

0.30.4

Protease Motifs9th

Hydrophobic Patch0th

087

Hydrophobic Interface Patch64th

1529

Pos. Charge Cluster73th

718

Neg. Charge Cluster0th

1015

Max Loop Length0th

Loop Flexibility55th

0.10.2

Buried Unsatisfied18th

Packing Density91th

12.314.5

Min Packing Density64th

Hydrophobic Fraction36th

0.30.5

Charge Asymmetry0th

0.20.5

Exposed Hydrophobic73th

00.1

PRODIGY ΔG9th

-13.6-8.7

PRODIGY Kd9th

iPTM100th

0.10.9

RMSD41th

0.212.2

pLDDT93th

0.60.9

EpitopeE01

Target Contacts (29)

A:GLN43A:PHE44A:LEU45A:TYR46A:PHE47A:ARG65A:GLU67A:LYS71A:TYR89A:TYR90A:TYR91A:GLN92A:CYS93A:TYR94A:PHE95A:SER96A:LYS97A:LYS98A:THR99A:ASN100+9 more

Interface SASA47.7%

Interface Hydrophob.53.7%

Surface Hydrophob.0.3

dSASA1807.4

Shape Complementarity0.68

Interface Residues21

Binder RMSD0.46Å

Hotspot RMSD0.66Å

Unrelaxed Clashes1

Binder

Binder Helix81.7%

Binder Loop18.3%

Interface

Interface Helix93.3%

Interface Loop6.7%

MPNN Score0.81

Seq Recovery0.67

AF2 pLDDT0.92

iPTM0.86

pTM0.91

iPAE0.19

Binder pLDDT0.95

Binder pTM0.78

Binder PAE0.08

STAPHYLOCOCCAL ENTEROTOXIN B2

STAPHYLOCOCCAL ENTEROTOXIN B2

Binder Sequence

vs. Siblings (29 in target)

Epitope Context

Interface Quality

Structural Fit

Secondary Structure

MPNN Quality

AF2 Confidence

Risk Flags

Interface AA Composition