Candidate SEB_01_A · STAPHYLOCOCCAL ENTEROTOXIN B2

SEB_01_All_Generators_bindcraft_binder_007

RankedPatch P01bindcraft75 aa

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Representation

KKVSVEEFEDIVMALLYTYGFDMSEEEKEKIYKEVMEIAKTEGVEKAWELFKEKMKKYVPEFPEYILNTPIEQMM

75 residuesBinder chain BTarget chain A

Unified Score9th

0.70.8

Solubility27th

0.60.8

3D-SAP9th

-3.5-1.5

pI64th

4.49.8

Interface Core82th

2747

Interface Rim18th

1524

Scaffold Exposed9th

Scaffold Buried0th

024

Low-Conf. Interface40th

00.7

Interface pLDDT73th

65.492

Scaffold pLDDT91th

5895.3

Lys+Arg Exposed45th

0.61

Mean Exposure18th

0.30.4

Protease Motifs9th

Hydrophobic Patch0th

087

Hydrophobic Interface Patch91th

1529

Pos. Charge Cluster27th

718

Neg. Charge Cluster27th

1015

Max Loop Length36th

Loop Flexibility0th

0.10.2

Buried Unsatisfied0th

Packing Density73th

12.314.5

Min Packing Density100th

Hydrophobic Fraction0th

0.30.5

Charge Asymmetry27th

0.20.5

Exposed Hydrophobic18th

00.1

PRODIGY ΔG73th

-13.6-8.7

PRODIGY Kd73th

iPTM90th

0.10.9

RMSD41th

0.212.2

pLDDT83th

0.60.9

EpitopeE01

Target Contacts (32)

A:ASN23A:GLN43A:PHE44A:LEU45A:TYR46A:PHE47A:ASP48A:ARG65A:GLU67A:PHE68A:LYS69A:ASN70A:LYS71A:LYS78A:TYR89A:TYR91A:GLN92A:CYS93A:TYR94A:PHE95+12 more

Interface SASA44.6%

Interface Hydrophob.68.3%

Surface Hydrophob.0.29

dSASA1957.3

Shape Complementarity0.63

Interface Residues21

Binder RMSD1.81Å

Hotspot RMSD0.74Å

Unrelaxed Clashes0.5

Binder

Binder Helix73.3%

Binder Loop26.7%

Interface

Interface Helix62.9%

Interface Loop37.1%

MPNN Score0.79

Seq Recovery0.51

AF2 pLDDT0.91

iPTM0.83

pTM0.9

iPAE0.21

Binder pLDDT0.84

Binder pTM0.71

Binder PAE0.17

SEB_01_All_Generators_bindcraft_binder_007

RankedPatch P01bindcraft75 aa

Loading structure…

Representation

KKVSVEEFEDIVMALLYTYGFDMSEEEKEKIYKEVMEIAKTEGVEKAWELFKEKMKKYVPEFPEYILNTPIEQMM

75 residuesBinder chain BTarget chain A

Unified Score9th

0.70.8

Solubility27th

0.60.8

3D-SAP9th

-3.5-1.5

pI64th

4.49.8

Interface Core82th

2747

Interface Rim18th

1524

Scaffold Exposed9th

Scaffold Buried0th

024

Low-Conf. Interface40th

00.7

Interface pLDDT73th

65.492

Scaffold pLDDT91th

5895.3

Lys+Arg Exposed45th

0.61

Mean Exposure18th

0.30.4

Protease Motifs9th

Hydrophobic Patch0th

087

Hydrophobic Interface Patch91th

1529

Pos. Charge Cluster27th

718

Neg. Charge Cluster27th

1015

Max Loop Length36th

Loop Flexibility0th

0.10.2

Buried Unsatisfied0th

Packing Density73th

12.314.5

Min Packing Density100th

Hydrophobic Fraction0th

0.30.5

Charge Asymmetry27th

0.20.5

Exposed Hydrophobic18th

00.1

PRODIGY ΔG73th

-13.6-8.7

PRODIGY Kd73th

iPTM90th

0.10.9

RMSD41th

0.212.2

pLDDT83th

0.60.9

EpitopeE01

Target Contacts (32)

A:ASN23A:GLN43A:PHE44A:LEU45A:TYR46A:PHE47A:ASP48A:ARG65A:GLU67A:PHE68A:LYS69A:ASN70A:LYS71A:LYS78A:TYR89A:TYR91A:GLN92A:CYS93A:TYR94A:PHE95+12 more

Interface SASA44.6%

Interface Hydrophob.68.3%

Surface Hydrophob.0.29

dSASA1957.3

Shape Complementarity0.63

Interface Residues21

Binder RMSD1.81Å

Hotspot RMSD0.74Å

Unrelaxed Clashes0.5

Binder

Binder Helix73.3%

Binder Loop26.7%

Interface

Interface Helix62.9%

Interface Loop37.1%

MPNN Score0.79

Seq Recovery0.51

AF2 pLDDT0.91

iPTM0.83

pTM0.9

iPAE0.21

Binder pLDDT0.84

Binder pTM0.71

Binder PAE0.17

Binder Sequence

vs. Siblings (29 in target)

Epitope Context

Interface Quality

Structural Fit

Secondary Structure

MPNN Quality

AF2 Confidence

Risk Flags

Interface AA Composition

STAPHYLOCOCCAL ENTEROTOXIN B2

Binder Sequence

vs. Siblings (29 in target)

Epitope Context

Interface Quality

Structural Fit

Secondary Structure

MPNN Quality

AF2 Confidence

Risk Flags

Interface AA Composition

STAPHYLOCOCCAL ENTEROTOXIN B2