Candidate SEB_01_A · STAPHYLOCOCCAL ENTEROTOXIN B2

SEB_01_All_Generators_bindcraft_binder_008

PromisingPatch P01bindcraft75 aa

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Representation

KKVSVEEFKDIVMALLYTYGFDMSDEEKKEIFDKVMEIAKTEGVEKAWEEFKKEMKKYVPEFPEYILNTPIEQMM

75 residuesBinder chain BTarget chain A

Unified Score18th

0.70.8

Solubility45th

0.60.8

3D-SAP0th

-3.5-1.5

pI55th

4.49.8

Interface Core73th

2747

Interface Rim36th

1524

Scaffold Exposed9th

Scaffold Buried0th

024

Low-Conf. Interface40th

00.7

Interface pLDDT64th

65.492

Scaffold pLDDT100th

5895.3

Lys+Arg Exposed55th

0.61

Mean Exposure9th

0.30.4

Protease Motifs9th

Hydrophobic Patch0th

087

Hydrophobic Interface Patch91th

1529

Pos. Charge Cluster36th

718

Neg. Charge Cluster27th

1015

Max Loop Length36th

Loop Flexibility0th

0.10.2

Buried Unsatisfied0th

Packing Density82th

12.314.5

Min Packing Density100th

Hydrophobic Fraction9th

0.30.5

Charge Asymmetry36th

0.20.5

Exposed Hydrophobic64th

00.1

PRODIGY ΔG45th

-13.6-8.7

PRODIGY Kd45th

iPTM86th

0.10.9

RMSD41th

0.212.2

pLDDT83th

0.60.9

EpitopeE01

Target Contacts (32)

A:ASN23A:GLN43A:PHE44A:LEU45A:TYR46A:PHE47A:ARG65A:GLU67A:PHE68A:LYS69A:ASN70A:LYS71A:LYS78A:TYR89A:TYR91A:GLN92A:CYS93A:TYR94A:PHE95A:SER96+12 more

Interface SASA46.3%

Interface Hydrophob.71%

Surface Hydrophob.0.29

dSASA1989.7

Shape Complementarity0.62

Interface Residues19

Binder RMSD1.85Å

Hotspot RMSD0.85Å

Unrelaxed Clashes0

Binder

Binder Helix73.3%

Binder Loop26.7%

Interface

Interface Helix62.9%

Interface Loop37.1%

MPNN Score0.79

Seq Recovery0.53

AF2 pLDDT0.91

iPTM0.82

pTM0.9

iPAE0.21

Binder pLDDT0.83

Binder pTM0.7

Binder PAE0.17

SEB_01_All_Generators_bindcraft_binder_008

PromisingPatch P01bindcraft75 aa

Loading structure…

Representation

KKVSVEEFKDIVMALLYTYGFDMSDEEKKEIFDKVMEIAKTEGVEKAWEEFKKEMKKYVPEFPEYILNTPIEQMM

75 residuesBinder chain BTarget chain A

Unified Score18th

0.70.8

Solubility45th

0.60.8

3D-SAP0th

-3.5-1.5

pI55th

4.49.8

Interface Core73th

2747

Interface Rim36th

1524

Scaffold Exposed9th

Scaffold Buried0th

024

Low-Conf. Interface40th

00.7

Interface pLDDT64th

65.492

Scaffold pLDDT100th

5895.3

Lys+Arg Exposed55th

0.61

Mean Exposure9th

0.30.4

Protease Motifs9th

Hydrophobic Patch0th

087

Hydrophobic Interface Patch91th

1529

Pos. Charge Cluster36th

718

Neg. Charge Cluster27th

1015

Max Loop Length36th

Loop Flexibility0th

0.10.2

Buried Unsatisfied0th

Packing Density82th

12.314.5

Min Packing Density100th

Hydrophobic Fraction9th

0.30.5

Charge Asymmetry36th

0.20.5

Exposed Hydrophobic64th

00.1

PRODIGY ΔG45th

-13.6-8.7

PRODIGY Kd45th

iPTM86th

0.10.9

RMSD41th

0.212.2

pLDDT83th

0.60.9

EpitopeE01

Target Contacts (32)

A:ASN23A:GLN43A:PHE44A:LEU45A:TYR46A:PHE47A:ARG65A:GLU67A:PHE68A:LYS69A:ASN70A:LYS71A:LYS78A:TYR89A:TYR91A:GLN92A:CYS93A:TYR94A:PHE95A:SER96+12 more

Interface SASA46.3%

Interface Hydrophob.71%

Surface Hydrophob.0.29

dSASA1989.7

Shape Complementarity0.62

Interface Residues19

Binder RMSD1.85Å

Hotspot RMSD0.85Å

Unrelaxed Clashes0

Binder

Binder Helix73.3%

Binder Loop26.7%

Interface

Interface Helix62.9%

Interface Loop37.1%

MPNN Score0.79

Seq Recovery0.53

AF2 pLDDT0.91

iPTM0.82

pTM0.9

iPAE0.21

Binder pLDDT0.83

Binder pTM0.7

Binder PAE0.17

Binder Sequence

vs. Siblings (29 in target)

Epitope Context

Interface Quality

Structural Fit

Secondary Structure

MPNN Quality

AF2 Confidence

Risk Flags

Interface AA Composition

STAPHYLOCOCCAL ENTEROTOXIN B2

Binder Sequence

vs. Siblings (29 in target)

Epitope Context

Interface Quality

Structural Fit

Secondary Structure

MPNN Quality

AF2 Confidence

Risk Flags

Interface AA Composition

STAPHYLOCOCCAL ENTEROTOXIN B2